The use of new diagnostic and therapeutic technologies has significantly reduced the number of severe forms of the GDT and mortality from them. However, with the development of medicine, new issues of diagnosis and treatment of infectious diseases in obstetrics arise, which need further study. The features of modern obstetrics and gynecology are changes in the number of pregnant women and puerperas (an increase in the number of women with severe extragenital pathology, induced pregnancy, hormonal and surgical correction of miscarriage, etc.), a high frequency of abdominal delivery, and the widespread use of advanced antimicrobial drugs for preventive and therapeutic purposes. spectrum of action, leading to the accumulation of antibiotic-resistant strains of microorganisms in institutions, and Use of invasive examination and treatment methods. It should also take into account the increasing use during pregnancy of various drugs, including corticosteroids and cytotoxic drugs with immunosuppressive effects.
In the complex therapy of the GD, the leading role belongs to antibacterial drugs. Over the past decade, there has been an increase in the use of antibiotics throughout the world, but this trend varies significantly between countries.
The variability of the etiological structure of the GDH, the growth of microbial resistance to antibiotics leads to the need to constantly update and expand the range of these drugs. In this regard, there is a need for periodic review of their use in the treatment of inflammatory diseases in all areas of medicine, including in obstetrics and gynecology.
Antibiotics are the most numerous group of drugs. Thus, in Russia at present, 30 different groups of antibiotics are used, and the number of drugs (excluding non-original) is approaching 200. In the US, antibiotics have been shown to be one of the most frequently prescribed drugs for pregnant women: 3 out of 5 drugs used during pregnancy are antibacterial agents . Despite the fact that a small number of studies have revealed the possible negative effects of antibiotic therapy during pregnancy, the frequency of use of antimicrobial agents during gestation remains largely unknown. A population cohort study, conducted in Denmark from 2000 to 2010, revealed that antibiotics were prescribed in 33.4% of cases among all deliveries and in 12.6% among all artificial interruptions of pregnancy, while from 2000 to 2010 Antimicrobial prescription increased from 28.4% to 37.0%. In a study by L. de Jonge et al., It was shown that at least one antibacterial drug was prescribed in 20.8% of patients during pregnancy, while β-lactam antibiotics were used most often. It is worth noting that similar trends are observed in many countries around the world.