Latin name: Clomid
ATX Code: G03GB02
Active ingredient: clomiphene (clomifene)
Producer: Bruno Farmaceutici SpA (Italy), Marion Merrell Burgoin (France)
Clomid is an antiestrogenic agent.
Release form and composition
Dosage form – tablets (10 pcs. In blisters, in a box of 10 blisters).
The active substance is clomiphene citrate, in 1 tablet – 50 mg.
Pharmacological properties
Pharmacodynamics
Clomid-info.com is an anti-estrogenic drug of non-steroidal structure.
Stimulates the ovulation process, while the exact mechanism of action remains unclear. It is believed that the active substance of the drug, clomiphene, blocks estrogen receptors in the ovaries and hypothalamus and, by feedback, enhances the synthesis of gonadotropic hormones (luteinizing hormone and follicle-stimulating hormone) by the pituitary gland. In turn, this has a stimulating effect on the maturation and endocrine activity of the follicle in the ovary, and then on the process of formation and functioning of the corpus luteum.
Pharmacokinetics
After oral administration, clomiphene is rapidly absorbed from the gastrointestinal tract. At the end of the 5-day therapy, its cumulative excretion is 50% of the dose taken (42.2% with feces, 7.8% with urine). In the period from the 31st to the 35th day of therapy, 0.73% of the dose of the drug with feces and urine is daily excreted, and from the 42nd to the 45th day of therapy – 0.54%.
Indications for use
The use of the drug is indicated to stimulate ovulation in infertility on the background of secondary ovarian hypofunction, mainly due to disorders of the hypothalamic-pituitary system.
Contraindications
- uterine bleeding of unknown etiology;
- severe renal and / or liver failure;
- ovarian cyst;
- bleeding;
- lack of function or pituitary tumor;
- period of pregnancy.
Instructions for use Clomid: method and dosage
Clomid tablets are used internally.
Start taking should be on the fifth day of the menstrual cycle.
Recommended dosage: first cycle – 50 mg once a day for 5 days. If ovulation occurs in subsequent cycles of therapy, an increase in dose is not required.
In the absence of a clinical effect in the first cycle, after 30 days, a second cycle of treatment should be carried out with a daily dose of 100 mg for 5 days. Extension of the course of therapy or increase in dose in the second cycle should not be made.
For most women, a full course of 3 cycles is effective. In the absence of ovulation, it is not advisable to continue treatment.
Side effects
- cystic ovarian enlargement;
- tides;
- nausea;
- dizziness,
- headache;
- vision disorder.
Overdose
The main symptoms: visual impairment, flushing, nausea, vomiting.
Therapy: withdrawal of Clomid, symptomatic treatment.
Special instructions
Use the drug only as directed by your doctor.
Pregnancy and lactation
According to the instructions, Clomid is not prescribed during pregnancy and lactation.
With impaired renal function
Drug therapy for severe renal failure is contraindicated.
With impaired liver function
Therapy with severe liver failure is contraindicated.
Drug interaction
Clinically significant interaction of Clomid when combined with other drugs has not been established.
Analogs
Clomid’s analogues are: Clomiphene citrate, Clomiphene, Serofen, Klostilbegit, Serpafar.
Terms and conditions of storage
Keep out of the reach of children.
Store in a dry place protected from direct sunlight at temperatures up to 25 ° C. Shelf life is 5 years. Conditions of dispensing from pharmacies Dispatched by prescription.
Clomid Reviews
Reviews about Clomid are few. In most cases, the drug is highly effective, although there are also women for whom the therapeutic effect was insufficient. There are reports of the development of adverse reactions, usually in the form of pain in the lower abdomen.