Creutzfeldt-Jakob disease – synonyms, diagnosis, treatment

Creutzfeldt-Jakob disease – synonyms, diagnosis, treatment

Definition of Creutzfeldt-Jakob disease. Subacute spongy encephalopathy (related to the disease kuru, scrapie, bovine spongy encephalopathy = BSE, “mad cow disease”), “prion disease”

Epidemiology of Creutzfeldt-Jakob disease. Incidence is 0.8 per 1 million people.

Etiopathogenesis of Creutzfeldt-Jakob disease:
– Slow virus (prion)
– Theory of prions: a prion gene on chromosome 20
– 15% – familial form, 85% – sporadic form
– Iatrogenic (“infectious protein”): instrumental skid, during transplantation of the membrane or cornea or treatment using growth hormone

The main symptoms of Creutzfeldt-Jakob disease. Rapidly progressing dementia with movement disorders

Diagnosis of Creutzfeldt-Jakob disease:
– ICD-10 Dementia in Creutzfeldt-Jakob disease (F02.1)
– Rapidly progressing dementia
– Pyramidal and extrapyramidal symptoms, aphasia
– Typical pathological changes in EEG: three-phase waves
– Markers: neuron-specific enolase (NSE), the presence of the protein P130 and P131

Treatment. Symptomatic
Forecast. Fatal over a short period of time

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